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The need for a functional cure in the treatment of Severe Aortic Stenosis

Patients suffering from Severe Aortic Stenosis benefit from aortic valve replacement (AVR) therapy, both surgical, and more recently, via more minimally invasive approaches such as TAVR. However, life expectancy is yet to be fully restored via available therapies, and studies show that the younger a patient is, the greater the impact on long term survival. Younger and lower risk patients tend to be more active and would benefit from a valve replacement which most approximates normal function.

Next Generation TAVR will Last Longer & Work Better

The next generation of valves will need to address both the acute needs in terms of superior hemodynamic profile, as well as chronic needs in their ability to sustain that profile longer, over the lifetime of the patient. As we move into the future and toward younger, more active patients, addressing the need for a more effective and durable therapy will become more important.

The table below outlines the severity of the AS along with the different parameters of heart valve hemodynamics. In terms of the total valve dimensions, a normal aortic valve area is approximately 3–4 cm² and symptoms of AS begin when the aortic valve area reaches ≤1 cm².

DurAVR™ THV is designed to Last Longer & Work Better and has the potential to deliver a functional cure, shifting the patients from severe Aortic Stenosis to healthier aortic valve dynamics.

Table: Hemodynamic Parameters for Aortic Stenosis patients

Severe Aortic Valve Stenosis

Severe Aortic Stenosis is a narrowing of the aortic valve opening. This narrowing keeps the valve from opening fully, reducing blood flow to the body and making the heart work harder.

Symptoms of Aortic Stenosis include:

  • Chest pain
  • Dizziness
  • Fatigue
  • Out of breath
  • Irregular heartbeat

Causes of Aortic Stenosis include:

  • Age
  • Calcium buildup
  • Infection of heart tissue
  • Failing aortic surgical valve